What are the treatment protocols for metastatic anal cancer?

Updated: Apr 07, 2020
  • Author: Jeffrey B VanDeusen, MD, PhD; Chief Editor: N Joseph Espat, MD, MS, FACS  more...
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Answer

Answer

Stage IV (any T, any N, M1):

Metastatic disease is commonly treated with platinum-based chemotherapy. Regimens may include 5-FU or other agents. [2, 4]

Cisplatin + 5-FU:

  • Cisplatin 60 mg/m 2 day 1 plus  5-FU 1000 mg/m 2/d IV continuous infusion on days 1–4; repeat every 3 weeks  or
  • Cisplatin 75 mg/m 2 day 1  plus  5-FU 750 mg/m 2/d IV continuous infusion on days 1–4; repeat every 4 weeks 

mFOLFOX: 

  • Oxaliplatin 85 mg/m 2 IV day 1 plus
  • Leucovorin 400 mg/m 2 IV day 1 plus
  • 5-FU 400 mg/m 2 IV bolus on day 1, then 1200 mg/m 2/d x 2 days (total 2400 mg/m 2 over 46–48 hours) IV continuous infusion
  • Repeat every 2 weeks 

Carboplatin + paclitaxel

Subsequent therapy may include the following [2] :


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