Which age groups have the highest prevalence of erythromelalgia?

Updated: Sep 17, 2018
  • Author: Antoine N Saliba, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In early reports, the median age of onset of the early-onset form was 10 years. Adult-onset erythromelalgia has a wide age distribution, with most cases occurring in the fifth and sixth decades.

After an analysis of 32 pediatric cases treated over a 37-year period at the Mayo Clinic, researchers concluded that the majority of cases are not inherited and that progress of the disease is variable. No safe or reliable treatment has been established, and the erythromelalgia in the pediatric population is associated with substantial morbidity and, sometimes, death. [26]

In the Norwegian case series, patients were classified as having primary or secondary erythromelalgia. [18] The age range in the primary group (which could include patients with early-onset and idiopathic adult-onset disease) was 7-76 years, and the age range in the secondary group was 18-81 years. In the Mayo Clinic series, the median age was 60 years, and the age range was 5-91 years.


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