Which medications in the drug class Antineoplastic agents are used in the treatment of Erythroleukemia?

Updated: Dec 16, 2018
  • Author: Beata Holkova, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Antineoplastic agents

Antineoplastic agents are used for induction or consolidation therapy. They include cytarabine, daunorubicin, idarubicin, and mitoxantrone.

Cytarabine

Cytarabine is cell cycle S phase specific. It blocks the progression from G1 to S phase. It is converted intracellularly to the active compound cytarabine-5'-triphosphate, which inhibits DNA polymerase.

Daunorubicin (Cerubidine)

Daunorubicin is an anthracycline antibiotic. It binds to nucleic acids by intercalation between base pairs of DNA, interfering with DNA synthesis. It causes inhibition of DNA topoisomerase II.

Idarubicin (Idamycin PFS)

Idarubicin inhibits cell proliferation by inhibiting DNA and RNA polymerase.

Mitoxantrone (Novantrone)

Idarubicin inhibits cell proliferation by inhibiting DNA and RNA polymerase.


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