What is the role of lumbar puncture in the workup of erythroleukemia?

Updated: Dec 16, 2018
  • Author: Beata Holkova, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Lumbar puncture (LP) is performed if CNS or meningeal signs are present. LP usually reveals an elevated opening pressure, increased protein, and a low glucose level in the cerebrospinal fluid (CSF). If circulating blasts are present at the time of LP, intrathecal chemotherapy should be administered. LP is also suggested for patients who are asymptomatic but have circulating leukemic cell counts higher than 50,000/µL or an elevated LDH level.


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