What is the role of P-glycoprotein measurement in the workup of erythroleukemia?

Updated: Dec 16, 2018
  • Author: Beata Holkova, MD; Chief Editor: Emmanuel C Besa, MD  more...
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P-glycoprotein (Pgp) is a product of the MDR1 gene. It can be measured by means of either (1) immunohistochemistry (low sensitivity) or (2) flow cytometry with MRK16 or U1C1 antibodies (specific). This test should be considered in patients who do not respond to induction chemotherapy.

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