What are the WHO diagnostic criteria for pure erythroid leukemia?

Updated: Dec 16, 2018
  • Author: Beata Holkova, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Under the 2016 WHO classification, a diagnosis of pure erythroid leukemia requires the following [3, 12] :

  • >80% immature erythroid precursors with ≥30% proerythroblasts
  • < 20% myeloblasts
  • No prior therapy
  • No WHO genetic abnormality present

Severe pernicious anemia manifesting with pancytopenia can occasionally mimic erythroleukemia on bone marrow morphology. In such instances, waiting for the results of a complete workup, including cytogenetics and flow cytometry, before initiating treatment is recommended. B-12 and folate levels should similarly be reviewed before treatment.


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