What are the signs and symptoms of erythroleukemia?

Updated: Dec 16, 2018
  • Author: Beata Holkova, MD; Chief Editor: Emmanuel C Besa, MD  more...
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At presentation, the signs and symptoms of erythroleukemia are usually nonspecific and are attributable to the decreased hematopoiesis resulting from the replacement of bone marrow by leukemic cells. This decrease results in anemia, thrombocytopenia, and leukopenia. [10]

Patients rarely present with symptoms lasting longer than 6 months, and they are usually diagnosed within 1-3 months after the onset of symptoms. The most common presenting symptoms are as follows:

  • Fatigue or malaise

  • Minimal-to-modest weight loss

  • Easy bruising

  • Fever

  • Bone or abdominal pain

  • Dyspnea

  • Meningeal signs and symptoms (very rare, only if leukemic involvement of the central nervous system [CNS] is present)

  • Diffuse joint pain (nonspecific in one third of patients)

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