What are contraindications for platelet-rich plasma (PRP) knee injections?

Updated: Aug 09, 2018
  • Author: Quan Dang Le, MD; Chief Editor: Thomas M DeBerardino, MD  more...
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Absolute contraindications for PRP knee injections include the following:

  • Critical thrombocytopenia
  • Hemodynamic instability or septicemia
  • Septic arthritis, overlying cellulitis, or adjacent osteomyelitis
  • Platelet dysfunction syndrome

Relative contraindications to PRP knee injections include the following:

  • Regular nonsteroidal anti-inflammatory drug (NSAID) use within 48 hours of the procedure
  • Corticosteroid injection of the knee within 1 month or systemic corticosteroid use within 2 weeks
  • Recent fever or illness
  • Cancer, particularly of bone or blood
  • Anemia, with a hemoglobin level lower than 10 g/dL
  • Thrombocytopenia, with a platelet count lower than 10 5/μL

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