Which medications in the drug class Recombinant Human Activated Protein C are used in the treatment of Disseminated Intravascular Coagulation (DIC)?

Updated: Dec 06, 2020
  • Author: Marcel M Levi, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Recombinant Human Activated Protein C

Recombinant human APC inhibits factors Va and VIIIa of the coagulation cascade. It may also inhibit plasminogen activator inhibitor-1 (PAI-1). Drotrecogin alfa (Xigris) was withdrawn from the worldwide market on October 25, 2011.

Drotecogin alfa (Xigris)

Withdrawn from the worldwide market on October 25, 2011. Drotrecogin alfa was approved for the reduction of mortality in patients who have severe sepsis associated with acute organ dysfunction and who are at high risk for death. It is a recombinant form of human APC that exerts an antithrombotic effect by inhibiting factors Va and VIIIa.

Drotrecogin alfa exercises indirect profibrinolytic activity by inhibiting PAI-1 and limiting formation of activated thrombin-activatable fibrinolysis inhibitor. It may exert an anti-inflammatory effect by inhibiting human tumor necrosis factor (TNF) production by monocytes, blocking leukocyte adhesion to selectins, and limiting thrombin-induced inflammatory responses within the microvascular endothelium.

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