Which medications in the drug class Blood Components are used in the treatment of Disseminated Intravascular Coagulation (DIC)?

Updated: Dec 06, 2020
  • Author: Marcel M Levi, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

Blood Components

Blood components are used to correct abnormal hemostatic parameters. These products should be considered only after initial supportive and anticoagulant therapy. Washed packed red blood cells (PRBCs) and platelet concentrates are considered safe in uncontrolled DIC. Specialized blood components (eg, cryoprecipitate and fresh frozen plasma [FFP]) may interfere with or alleviate DIC.

Packed red blood cells (PRBCs; washed)

PRBCs are preferred to whole blood because they limit volume, immune, and storage complications. Obtain PRBCs after centrifugation of whole blood. Use washed or frozen PRBCs in individuals with hypersensitivity transfusion reactions.

Platelets

Platelets are considered safe for use in acute DIC.

Fresh frozen plasma (FFP)

FFP treatment entails removing blood from the body, spinning it to separate cells from plasma, and replacing cells suspended in fresh frozen plasma, albumin, or saline. FFP contains coagulation factors, as well as protein C and protein S. It can be administered either via 2 large-bore peripheral intravenous lines or via 1 multiple-lumen central line. It is recommended for patients with active bleeding and a fibrinogen level below 100 mg/dL.

Cryoprecipitate or fibrinogen concentrates

Cryoprecipitate and fibrinogen concentrates are not commonly recommended, except when fibrinogen is needed.


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