How has the Japanese Association for Acute Medicine (JAAM) diagnostic algorithm and scoring system for disseminated intravascular coagulation (DIC) been validated?

Updated: Dec 06, 2020
  • Author: Marcel M Levi, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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In a study of the JAAM DIC criteria in 79 patients with severe sepsis or septic shock, Umemura et al reported that the addition of two hemostatic endothelial molecular markers—protein C activity and plasminogen activator inhibitor 1—measured within 12 hours of admission, provided greater prognostic value, predicting mortality with a sensitivity of 84.6% and a specificity of 80.3%. Protein C activity correlated best with mortality, followed by plasminogen activator inhibitor 1. Using those criteria, DIC-positive patients also had significantly higher disease severity. [41]

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