What is the role of thrombomodulin testing in the workup of disseminated intravascular coagulation (DIC)?

Updated: Dec 06, 2020
  • Author: Marcel M Levi, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Evidence also suggests that serum levels of thrombomodulin, a marker for endothelial cell damage, correlate well with the clinical course of DIC, the development of multiple organ dysfunction syndrome (MODS), and mortality in septic patients. Thrombomodulin is elevated in DIC, and such elevation and not only correlates well with the severity of DIC but also can serve as a marker for early identification and monitoring of DIC. [65]

Regardless of the discussion above, most hospitals of all sizes in the developed world have available PT, aPTT, fibrinogen, platelet count, and D-dimer. These tests alone are sufficient to make or exclude a clinical diagnosis of DIC in the practice of medicine.

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