What are the most sensitive assays for the diagnosis of disseminated intravascular coagulation (DIC)?

Updated: Dec 06, 2020
  • Author: Marcel M Levi, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

In a specialized setting, molecular markers for activation of coagulation or fibrin formation may be the most sensitive assays for DIC. [64] A number of clinical studies show that the presence of soluble fibrin in plasma has a 90-100% sensitivity for DIC but, unfortunately, a relatively low specificity. As noted (see above) a reliable test for quantifying soluble fibrin in plasma is not available, and one study showed a wide discordance among various assays.


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