What is the prognosis and mortality rate of disseminated intravascular coagulation (DIC)?

Updated: Dec 06, 2020
  • Author: Marcel M Levi, MD; Chief Editor: Srikanth Nagalla, MBBS, MS, FACP  more...
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Answer

The prognosis of patients with DIC depends on the severity of the coagulopathy and on the underlying condition that led to DIC. Assigning numerical figures to DIC-specific morbidity and mortality is difficult. The following are examples of mortality figures for diseases complicated by DIC:

  • Idiopathic purpura fulminans associated with DIC has a mortality of 18%

  • Septic abortion with clostridial infection and shock associated with severe DIC has a mortality of 50%

  • In the setting of major trauma, the presence of DIC approximately doubles the mortality rate [12, 13]

A retrospective single-center Korean study of women with primary post-partum hemorrhage who presented to the emergency department found that 57 (22.4%) of the 255 patients had overt DIC. Of patients with DIC, 96.5% experienced major adverse events. [40]


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