What are the NCCN guidelines desired responses to first-line treatment for chronic myelogenous leukemia (CML)?

Updated: May 23, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

The desired responses to first-line treatment are as follows [21] :

  • 3 months: BCR-ABL1 transcripts ≤10% by qPCR 

  • 6 months: BCR-ABL1 transcripts ≤10% by qPCR 

  • 12 months: ≤1% BCR-ABL1

  • 15 months: ≤ 1% BCR-ABL1 

  • After BCR-ABL1 (IS) ≤1% (> 0.1%–1%) has been achieved, every 3 months for 2 years and every 3–6 months thereafter; if there is 1-log increase in BCR-ABL1 transcript levels with major molecular response, qPCR should be repeated in 1-3 months


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