Which tests are recommended by the guidelines for monitoring response to tyrosine kinase inhibitor (TKI) therapy of chronic myelogenous leukemia (CML)?

Updated: May 23, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

NCCN,  ELN, and ESMO guidelines recommend the following tests for monitoring response to TKI therapy [21, 22] :

  • Bone marrow cytogenetics

  • Quantitative reverse transcription polymerase chain reaction (qPCR) standardized by International Scale (IS)

The three guidelines vary in their recommendations regarding response to first-line treatment, as outlined below.


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