What is the recommended interval for peripheral blood testing in patients with chronic myelogenous leukemia (CML)?

Updated: May 23, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

The set guidelines of the European LeukemiaNet and the National Cancer Care Network suggest peripheral blood testing every 3 months for quantitative PCR. On a practical note, however, if a patient has been in an MMR (or, better yet, complete molecular remission) for months, it may be reasonable to extend the testing interval to every 6 months. If a significant change in BCR-ABL level occurs (negative to positive, or a > 2- to 5-fold increase in patients with detectable disease), then resuming more frequent testing is prudent.


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