How do additional chromosomal abnormalities (ACAs) affect the prognosis of chronic myelogenous leukemia (CML)?

Updated: May 23, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

A study by Wang et al addressed the prognostic impact of specific additional chromosomal abnormalities (ACAs) in CML. The concurrent presence of two or more ACAs conferred inferior survival. In patients with a single chromosomal change at the time of ACA emergence, the following three were associated with a relatively good prognosis [16] :

  • Trisomy 8
  • -Y
  • An extra copy of Philadelphia chromosome

In contrast, the following three ACAs were associated with a relatively poor prognosis:

  • i(17)(q10)
  • -7/7q (-7/del7q)
  • 3q26.2 rearrangements

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