Which therapy-associated factors may indicate a poor prognosis of chronic myelogenous leukemia (CML)?

Updated: May 23, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

The following therapy-associated factors may indicate a poor prognosis in patients with CML:

  • Longer time to hematologic remission with myelosuppression therapy

  • Short duration of remission

  • High total dose of hydroxyurea or busulfan

  • Poor suppression of Ph-positive cells by chemotherapy or interferon alfa therapy


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