What is the prognosis of chronic myelogenous leukemia (CML)?

Updated: Aug 25, 2020
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

Historically, the median survival of patients with CML was 3-5 years from the time of diagnosis. Currently, patients with CML have a median survival of 5 or more years. The 5-year survival rate has more than doubled, from 31% in the early 1990s to 69.2% for patients diagnosed from 2009 to 2015. [12, 11] The improvement has resulted from earlier diagnosis, improved therapy with targeted drugs and bone marrow transplantation, and better supportive care.

As treatment improved, the need to stage patients according to their prognoses became necessary to justify procedures with high morbidity and mortality, such as bone marrow transplantation.


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