Which bone marrow findings suggest chronic myelogenous leukemia (CML)?

Updated: May 23, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

Bone marrow findings

  • Ph1 (a reciprocal translocation of chromosomal material between chromosomes 9 and 22)
  • BCR/ABL mutation
  • Hypercellularity, with expansion of the myeloid cell line (eg, neutrophils, eosinophils, basophils) and its progenitor cells
  • Megakaryocytes are prominent and may be increased
  • Mild fibrosis in the reticulin stain

See Workup for more detail.


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