Which blood count and peripheral smear findings suggest chronic myelogenous leukemia (CML)?

Updated: May 23, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

Blood count and peripheral smear findings

  • Total WBC count 20,000-60,000 cells/μL, with mildly increased basophils and eosinophils
  • Mild to moderate anemia, usually normochromic and normocytic
  • Platelet counts low, normal, or increased
  • Leukocyte alkaline phosphatase stains very low to absent in most cells
  • Leukoerythroblastosis, with circulating immature cells from the bone marrow
  • Early myeloid cells (eg, myeloblasts, myelocytes, metamyelocytes, nucleated red blood cells)

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