What are the signs and symptoms of chronic myelogenous leukemia (CML)?

Updated: May 23, 2021
  • Author: Emmanuel C Besa, MD; Chief Editor: Sara J Grethlein, MD, FACP  more...
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Answer

The clinical manifestations of CML are insidious, changing somewhat as the disease progresses through its 3 phases (chronic, accelerated, and blast). Patients in the chronic phase may be asymptomatic or may display any of the following signs and symptoms:

  • Fatigue, weight loss, loss of energy, decreased exercise tolerance
  • Low-grade fever and excessive sweating from hypermetabolism
  • Elevated white blood cell (WBC) count or splenomegaly on routine assessment
  • Early satiety and decreased food intake from encroachment on stomach by enlarged spleen
  • Left upper quadrant abdominal pain from spleen infarction
  • Hepatomegaly

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