What are the racial predilections of factor IX deficiency (FIX) (hemophilia B)?

Updated: Mar 09, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Srikanth Nagalla, MD, MS, FACP  more...
  • Print
Answer

The disorder is found in all ethnic groups, and it does not have a specific ethnic or geographic distribution.

Ethnic differences in polymorphisms close to or in the FIX gene are important because they provide linkage data when identifying carriers, particularly when the mutation is unknown or for identification of de novo mutations.

A common G10430A mutation (Gly 60 Ser) in the factor IX gene was described in the moderate and mild hemophilia B in the majority of the Gujarati population. [14]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!