What are the goals of drug treatment in patients with aplastic anemia?

Updated: Jan 29, 2021
  • Author: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The goals of pharmacotherapy in cases of aplastic anemia are to reduce morbidity and prevent complications. Chelating agents are used to reduce iron overload in patients undergoing repeated transfusions. Immunosuppressive agents are used in conditioning regimens for hematopoietic stem cell transplantation; immunosuppression is also used for non-transplant therapy, most often with the combination of antithymocyte globulin (ATG) and cyclosporine.

Hematopoietic support with eltrombopag, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) may be considered in refractory infections, although the cost and efficacy of this therapy should be weighed. [10, 70, 71, 72, 106, 107]


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