Which conditioning regimens have shown good results in aplastic anemia (SAA)?

Updated: Jan 29, 2021
  • Author: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

According to a study by Samarasinghe et al, a conditioning regimen with fludarabine, cyclophosphamide, and alemtuzumab with matched unrelated-donor (MUD) HCT appears to be very well-suited in children with severe aplastic anemia and has excellent outcomes. [84] The investigators suggested that MUD HCT may be a reasonable alternative when immunosuppressive therapy fails. [84] In a study of fludarabine, low-dose cyclophosphamide, and alemtuzumab as a conditioning regimen for HCT (21 transplants from unrelated donors, with 3 of those from HLA 9/10 mismatch donors and 6 from matched sibling donors), Sheth et al reported similar outcomes in patients aged 50 years or older and those younger than 50 years. [82]


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