How do outcomes compare between horse antithymocyte globulin (ATG) and rabbit antithymocyte globulin (ATG) for conditioning in patients with aplastic anemia?

Updated: Jan 29, 2021
  • Author: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In a multinational study that included 287 patients with severe aplastic anemia who received ATG as part of their conditioning regimen for unrelated-donor HCT, rabbit ATG resulted in a lower incidence of acute (but not chronic) GVHD and better survival (3-year overall survival, 83% for rabbit ATG versus 75% for horse ATG; P=0.02). The authors concluded that these data support the use of rabbit ATG in this setting. [78] Typical regimens in this study population were horse ATG, cyclophosphamide, and low-dose total-body irradiation (TBI); and rabbit ATG, cyclophosphamide, fludarabine, and TBI.


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