How is fertility affected by high-dose cyclophosphamide conditioning in patients with aplastic anemia?

Updated: Jan 29, 2021
  • Author: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Patients receiving high-dose cyclophosphamide conditioning in allogeneic HCT from an HLA-identical sibling donor for aplastic anemia have relatively well-preserved fertility. [5] Provide these patients with appropriate contraceptive advice to prevent unintended pregnancies.

Longer-term data are limited for patients with fludarabine-based regimens. Therefore, discussions related to potential fertility preservation, including cryopreservation of sperm and oocytes/embryos, is recommended. [5] Cyclosporine is safe for use in pregnancy.


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