What are the differences between horse antithymocyte globulin (ATG) and rabbit antithymocyte globulin (ATG) for immunosuppressive therapy in aplastic anemia?

Updated: Jan 29, 2021
  • Author: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Although horse ATG is better than rabbit ATG as an immunosuppressive therapy, a multinational study of ATG used as part of the conditioning regimen, which included 546 HLA-matched sibling HCT transplants for severe aplastic anemia, found that 3-year overall survival rates were not significantly different with rabbit versus horse ATG. However, the day-100 incidences of both acute and chronic GVHD were higher with horse than with rabbit ATG (acute GHVD, 17% versus 6%, respectively, P < 0.001; chronic GVHD, 20% versus 9%, P < 0.001). The authors concluded that these results support the use of rabbit ATG for bone marrow conditioning. [78]

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