How is aplastic anemia differentiated from myelodysplastic syndrome (MDS)?

Updated: Jan 29, 2021
  • Author: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Aplastic anemia must be differentiated from myelodysplastic syndrome (MDS). The bone marrow in patients with aplastic anemia may have hyperplastic pockets, which can sometimes be confused with MDS; moreover, hypoplasia of bone marrow may be present in cases of hypoplastic  MDS. [64] However, in aplastic anemia, CD34 evaluation always reveals a low count; further, ringed sideroblasts, myeloblasts, and dysplastic megakaryocytes are never seen in aplastic anemia but are often seen in MDS.


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