What are the signs and symptoms of aplastic anemia?

Updated: Jan 29, 2021
  • Author: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells. The onset is insidious, and the initial symptom is frequently related to anemia or bleeding, although fever or infections may be noted at presentation. Specific manifestations include the following:

  • Anemia: May manifest as pallor, headache, palpitations, dyspnea, fatigue, or foot swelling
  • Thrombocytopenia: May result in mucosal and gingival bleeding or petechial rashes
  • Neutropenia: May manifest as overt infections, recurrent infections, or mouth and pharyngeal ulcerations

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