What are the survival rates for aplastic anemia following treatment?

Updated: Jan 29, 2021
  • Author: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

The estimated 10-year survival rate for the typical patient receiving immunosuppression is 68%, compared with 73% for hematopoietic cell transplantation (HCT). [45] However, there is a significantly improved outcome for HCT over time, for matched sibling and alternative donors, and with younger age. [45] In cases of immunosuppression, relapse and late clonal disease are risks.

In a single-institution analysis of 183 patients who received immunosuppressive treatments for severe aplastic anemia, the telomere length of peripheral blood leukocytes was unrelated to treatment response. [29] In a multivariate analysis, however, telomere length was associated with risk of relapse, clonal evolution, and overall survival. [29] Additional studies are needed to validate these findings and to determine how this information might be incorporated into treatment algorithms.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!