What are acquired causes of aplastic anemia?

Updated: Jan 29, 2021
  • Author: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Acquired causes of aplastic anemia (80%) include the following:

  • Idiopathic factors
  • Infectious causes, such as hepatitis viruses, [38] Epstein-Barr virus (EBV), human immunodeficiency virus (HIV), parvovirus, and mycobacteria
  • Exposure to ionizing radiation
  • Exposure to toxic chemicals, such as benzene or pesticides [39]
  • Transfusional graft versus host disease (GVHD)
  • Orthotopic liver transplantation for fulminant hepatitis
  • Pregnancy
  • Eosinophilic fasciitis
  • Anorexia
  • Severe nutritional deficiencies (vitamin B12, folate)
  • Paroxysmal nocturnal hemoglobinuria (PNH)
  • MDS
  • Acute lymphoblastic leukemia (ALL)(rarely)

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