What percentage of aplastic anemia is acquired?

Updated: Jan 29, 2021
  • Author: Sameer Bakhshi, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. [8, 9, 10, 11, 12]  This condition is characterized by both qualitative loss in functions as well as quantitative loss in stem cell numbers. The distinction between acquired and inherited disease may present a clinical challenge, but more than 80% of cases are acquired. External insults (eg, infections, radiation, drugs) may disrupt stem cell homeostasis in marrow environment, leading to altered growth. Clinical and laboratory observations suggest that acquired aplastic anemia is an autoimmune disease.


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