What are the genetic etiologic factors of abdominal aortic aneurysm (AAA)?

Updated: Jan 08, 2019
  • Author: Saum A Rahimi, MD, FACS; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

Persons who have first-degree relatives with AAA are at increased risk for AAA. The familial prevalence rate of AAA has been estimated at 15-25%. Studies by Majumder et al suggest that the genetic predisposition is isolated to a single dominant gene with low penetrance that increases with age. [8]

Tilson et al described the potential for an autoimmune basis for the development of AAA involving the DRB1 major histocompatibility locus. [9] This locus has been identified as a basis for inflammatory AAA.


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