What factors may trigger protease activation in the pathogenesis of abdominal aortic aneurysms (AAAs)?

Updated: Jan 08, 2019
  • Author: Saum A Rahimi, MD, FACS; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

Upon histologic examination, AAAs demonstrate a chronic adventitial and medial inflammatory infiltrate. Infiltration of AAAs with lymphocytes and macrophages may trigger protease activation via various cytokines (eg, interleukin [IL]-1, IL-6, IL-8, and tumor necrosis factor [TNF]-α).


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