Which mechanisms are involved in the pathogenesis of abdominal aortic aneurysm (AAA)?

Updated: Jan 08, 2019
  • Author: Saum A Rahimi, MD, FACS; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

A multidisciplinary research program supported by the US National Heart, Lung, and Blood Institute identified the following as mechanisms important in the development of AAA [3] :

  • Proteolytic degradation of aortic-wall connective tissue
  • Inflammation and immune responses
  • Biomechanical wall stress
  • Molecular genetics

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