What is the pathogenesis of abdominal aortic aneurysms (AAAs)?

Updated: Jan 08, 2019
  • Author: Saum A Rahimi, MD, FACS; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

AAAs arise as a result of a failure of the major structural proteins of the aorta (elastin and collagen). The inciting factors are not known, but a genetic predisposition clearly exists. Although aneurysms represent a dilatation in all layers of the vessel wall, AAAs develop after degeneration of the media. The degeneration ultimately may lead to widening of the vessel lumen and loss of structural integrity.


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