What is the role of pharmacologic therapy in the treatment of abdominal abscess?

Updated: Mar 27, 2020
  • Author: Alan A Saber, MD, MS, FACS, FASMBS; Chief Editor: John Geibel, MD, MSc, DSc, AGAF  more...
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Pharmacologic therapy involves the empiric administration of parenteral empiric antibiotics. This should be initiated before abscess drainage and concluded when all systemic signs of sepsis have resolved. Because abscess fluid usually contains a mixture of aerobic and anaerobic organisms, initial empiric therapy must be directed against both types of microbes. This may be accomplished with antibiotic combination therapy or with broad-spectrum single-agent therapy. Specific therapy is then guided by the results of cultures retrieved from the abscess. [5]

In patients who are immunosuppressed, candidal species may play an important pathogenic role, and treatment with amphotericin B may be indicated.

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