What are the National Comprehensive Cancer Network (NCCN) and European Society of Medical Oncology (ESMO) guidelines for the diagnostic workup for acute myeloid leukemia (AML)?

Updated: May 26, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Both the NCCN and ESMO guidelines recommend including the following tests in the diagnostic workup for AML [25, 112] :

  • Complete blood count (CBC) with manual differential and routine chemistry profile (including liver function tests, serum creatinine, lactate dehydrogenase [LDH], and uric acid)
  • Coagulation profile – Prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen
  • Bone marrow aspiration and biopsy, including classical cytogenetics, immunophenotyping, and molecular testing for  c-KIT, FLT3-ITD, FLT3-TKD, NPM1CEBPA,  IDH1, IDH2, TP53 and other mutations
  • HLA typing of patient and family

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