How is hyperuricemia treated in patients with acute myeloid leukemia (AML)?

Updated: May 26, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Allopurinol 300 mg should be given 1-3 times a day during induction therapy until the clearance of blasts and resolution of hyperuricemia. For patients who cannot tolerate oral medications, IV drugs such as rasburicase are an option. Rasburicase should  be administered to patients at high risk of severe tumor lysis, including those with very high white blood counts, very high lactate dehydrogenase [LDH] levels, and/or baseline renal insufficiency.


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