What is the role of posaconazole in the treatment of acute myeloid leukemia (AML)?

Updated: May 26, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In a randomized trial of posaconazole versus either fluconazole or itraconazole (selected on the basis of local practice) in patients with AML and myelodysplastic syndrome undergoing intensive chemotherapy, posaconazole proved more effective at preventing invasive fungal infections, including invasive asperglilosis. In addition, all-cause mortality at day 100 was significantly lower in patients who received posaconazole. However, serious adverse events possibly or probably related to treatment occurred more frequently in the posaconazole group. [104]


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