What are the histologic subtypes of acute promyelocytic leukemia (APL)?

Updated: May 26, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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There are two histologic subtypes of APL: hypergranular and hypogranular. In both cases the bone marrow contains atypical promyelocytes that have bilobed nuclei. In the hypergranular variant the cells contain large dense cytoplasmic granules, sheets of fine granules, and/or varying numbers of Auer rods. In the hypogranular variant granules are nearly absent and the cytoplasm has a pale appearance.

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