What are the treatment options for older patients who are not candidates for intensive chemotherapy for the treatment of acute myeloid leukemia (AML)?

Updated: May 26, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Other therapies are being studied in older patients who are not candidates for intensive chemotherapy. [74] As part of the National Cancer Research Institute Acute Myeloid Leukemia 14 Trial, 217 patients who were deemed unfit for intensive chemotherapy were randomized to receive low-dose cytarabine (20 mg twice daily for 10 d) or hydroxyurea with or without all-trans retinoic acid (ATRA). Low-dose cytarabine produced a better remission rate (18% vs 1%; P =0.00006) and better OS (odds ratio, 0.60; P =0.0009) OS was 80 weeks for patients achieving CR verus 10 weeks for patients with no remission. [75]


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