What are the NCCN guidelines for hematopoietic stem cell transplantation (HCT) in the treatment of acute myeloid leukemia (AML)?

Updated: May 26, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In patients younger than 60 years, National Comprehensive Cancer Network guidelines recommend matched sibling or alternate donor HCT as an option in the following situations [25] :

  • After induction failure with standard-dose or high-dose cytarabine
  • In patients with significant residual disease without a hypocellular marrow, after high-dose cytarabine induction therapy
  • As post-remission therapy in patients with intermediate-risk or poor-risk cytogenetics and/or molecular abnormalities, or those with treatment-related disease

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