What is the most commonly mutated gene in acute myeloid leukemia (AML)?

Updated: May 26, 2020
  • Author: Karen Seiter, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

FLT3 is the most commonly mutated gene in cases of AML and is constitutively activated in one third of AML cases. [30] Internal tandem duplications (ITDs) in the juxtamembrane domain of FLT3 exist in 25% of AML cases. In other cases, mutations exist in the activation loop of FLT3. Most studies demonstrate that patients with AML and FLT3-ITDs have a poor prognosis. Analysis of FLT3 is commercially available.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!