Which medications in the drug class Anticoagulants, Cardiovascular are used in the treatment of Cardiac Amyloidosis?

Updated: Mar 25, 2020
  • Author: Gyanendra K Sharma, MD, FACC, FASE; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Anticoagulants, Cardiovascular

The use of anticoagulants is restricted to patients in atrial fibrillation, with artificial valves, and with known mural thrombus. Some data support their use in patients with low ejection fractions.

Warfarin (Coumadin)

Warfarin interferes with the hepatic synthesis of vitamin K–dependent coagulation factors. Anticoagulation therapy is indicated in patients with atrial fibrillation or documented cardiac thrombi. It is also indicated in advanced amyloidosis with the loss of atrial function when thrombi can form even in presence of a sinus rhythm. [63] Usual starting dose of warfarin is 2.5-5 mg daily depending upon the age of the patient and comorbid conditions

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