Which medications in the drug class Alpha-Adrenergic Agonists are used in the treatment of Cardiac Amyloidosis?

Updated: Mar 25, 2020
  • Author: Gyanendra K Sharma, MD, FACC, FASE; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Alpha-Adrenergic Agonists

These agents may reduce sympathetic outflow, which may reduce muscle tone.


Midodrine is a prodrug with activity as an alpha1-adrenoreceptor agonist. This agent is widely used to treat orthostatic hypotension. Midodrine acts directly on the vasculature to increase BP and avoids electrolyte abnormalities associated with fludrocortisone. Fludrocortisone should be avoided because of risk of salt and water retention. Midodrine has often caused an unpleasant sensation in the scalp (due to piloerection).

Usual recommended dose of Midodrine is 10 mg by mouth 3 times daily.

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