Which patient groups have the highest prevalence of cardiac amyloidosis?

Updated: Mar 25, 2020
  • Author: Gyanendra K Sharma, MD, FACC, FASE; Chief Editor: Terrence X O'Brien, MD, MS, FACC  more...
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Answer

AL is uncommon in non-white individuals and persons younger than 40 years, [20] and it affects men and women equally. Senile amyloidosis, in which wild-type transthyretin (wt-TTR) accumulates in tissue and leads to the development of cardiac dysfunction, [21] is 3 times more common in elderly black patients compared to white patients (8.2% vs 2.7%, respectively) [22] and is more common in males. [23] Hereditary cardiac amyloidosis resulting from a mutation in TTR (>100 TTR variants [24] ) is more common in black individuals than white persons; 23% of the patients have this variant. [25]

AL type is usually seen in persons older than age 50 years. Although unusual, it can occur as early as the third decade of life. Late onset amyloidosis (senile) is seen in elderly patients and has a better prognosis than primary amyloidosis.


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