What is the duration of chemoprophylaxis for suspected influenza?

Updated: Oct 13, 2021
  • Author: Christian E Sandrock, MD, MPH, FCCP; Chief Editor: Michael Stuart Bronze, MD  more...
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Postexposure prophylaxis: 10 days when administered after a household exposure, or for high-risk patients, 7 days after the most recent known exposure when prophylaxis can be initiated within 48 hours of exposure

Pre-exposure prophylaxis: Dependent on duration of community outbreak as the antiviral needs to be taken every day during the outbreak to be maximally effective

Outbreaks in long-term care facilities and hospitals: Prophylaxis for ≥14 days and up to 7 days after the most recent known case was identified (CDC recommendation)

  • Oseltamivir: Up to 6 weeks

  • Zanamivir: Up to 4 weeks

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